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active constituent

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By Targets:	5 alpha Reductase (1) Antibiotic (1) Apoptosis (2) Autophagy (2) Bacterial (2) Chloride Channel (1) Cytochrome P450 (1) Drug Metabolite (3) Endogenous Metabolite (3) HBV (1) iGluR (1) NF-κB (1) NO Synthase (1) Notch (1) Phosphatase (1) Reactive Oxygen Species (2) RSV (1) TNF Receptor (1) TRP Channel (1) Tyrosinase (1) Wnt (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (7) Metabolic Disease (5) Neurological Disease (4)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1479

Polygalic acid

Polygalic acid, a triterpenoid saponin, is considered one of the major active constituents of Polygala tenuifolia .

Polygalic acid
Polygalic acid, a triterpenoid saponin, is considered one of the major active constituents of Polygala tenuifolia .

HY-N0267

Hypaconitine 2 Publications Verification	TNF Receptor	Inflammation/Immunology
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.

HY-N2909

Aurantiamide	Others	Inflammation/Immunology
Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities .

HY-N5064

Bacoside A3

Others Neurological Disease

Bacoside A3, a triterpenoid saponin, is one of the major active constituents in Bacopa monnieri. Bacoside A3 has neuroprotective activity .

Bacoside A3	Others	Neurological Disease
Bacoside A3, a triterpenoid saponin, is one of the major active constituents in Bacopa monnieri. Bacoside A3 has neuroprotective activity .

HY-W087444A

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol	Bacterial Antibiotic	Infection
(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol is an active constituent of the aerial parts of Angelica sinensis. (S)-1-(4-Hydroxyphenyl)ethane-1,2-diol significantly inhibits the growth of Aeromonas hydrophila. Anticoagulative and antibiotic activities .

HY-N7781

(-)-(E)-Guggulsterone (E)-Guggulsterone	Drug Metabolite	Metabolic Disease
(-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .

HY-135013

Umbellulone	TRP Channel	Neurological Disease
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism .

HY-N0804

Narirutin 2 Publications Verification	Bacterial	Inflammation/Immunology
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Endogenous Metabolite	Inflammation/Immunology
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-N0738

Stachydrine hydrochloride 3 Publications Verification	NF-κB Endogenous Metabolite	Cardiovascular Disease Cancer
Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases . Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities .

HY-N1995

Methylswertianin
Methylswertianin is an active constituent in Swertia punicea Hemsl, with anti-diabetic effect. Methylswertianin can abates type-2 diabetes, likely via the improvement of insulin resistance (IR) .

HY-N9363

Corymbiferin	Others	Metabolic Disease
Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells .

HY-N8810

Platycoside M1	Others	Others
Platycoside M1 is a A-ring lactone triterpenoid saponin that can be isolaoted from the roots of Platycodon grandiflorum. Platycosides are the main active constituents of P. grandiflorus with multiple pharmacological activities .

HY-N1481

Methyl linoleate	Tyrosinase	Metabolic Disease
Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins .

HY-N0268

Irisflorentin	NO Synthase	Inflammation/Immunology
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-N1179

Tanshinone IIB
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used for the research of stroke and coronary heart disease in Asian countries. Tanshinone IIB has a neuroprotective effect via inhibition of apoptosis .

HY-N0008

Orcinol glucoside	Wnt	Neurological Disease
Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

HY-N10322

2-Hydroxyemodin	Drug Metabolite	Others
2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system .

HY-129692

Withanone	iGluR	Neurological Disease
Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells .

HY-W040265

Fenamic acid N-Phenylanthranilic acid	Chloride Channel	Inflammation/Immunology
Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent ^- .

HY-N7781R

(-)-(E)-Guggulsterone (Standard) (E)-Guggulsterone (Standard)	Drug Metabolite	Metabolic Disease
(-)-(E)-Guggulsterone (Standard) is the analytical standard of (-)-(E)-Guggulsterone. This product is intended for research and analytical applications. (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .

HY-N12141

Flaccidoside II	Apoptosis	Inflammation/Immunology
Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-W013605A

4-Methoxycinnamaldehyde p-Methoxycinnamaldehyde	RSV	Infection
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC₅₀ of 0.055 μg/mL .

HY-N0692

Schisandrol B 1 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Reactive Oxygen Species Cytochrome P450 Autophagy	Cancer
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N0646

Silydianin 1 Publications Verification	Phosphatase Endogenous Metabolite	Cancer
Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products .

HY-N0502

Mogroside V	Reactive Oxygen Species	Metabolic Disease Cancer
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-N7695

Physalin B	Apoptosis Autophagy	Cancer
Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro .

HY-N7510

12-O-Methylcarnosic acid 12-Methoxycarnosic acid	5 alpha Reductase	Infection Cancer
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC₅₀ value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .

HY-N1365

Isoscopoletin 6-Hydroxy-7-methoxycoumarin	HBV	Infection Cancer
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC₅₀s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively . Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication .

HY-N9790

Procyanidin B2 3,3'-di-O-gallate	Notch	Others
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .

Hypaconitine 2 Publications Verification	Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	TNF Receptor
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.

Aurantiamide	Alkaloids Classification of Application Fields Source classification Plants Umbelliferae Disease Research Fields Inflammation/Immunology Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities .

Bacoside A3	Triterpenes Terpenoids Source classification Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst.	Others
Bacoside A3, a triterpenoid saponin, is one of the major active constituents in Bacopa monnieri. Bacoside A3 has neuroprotective activity .

(-)-(E)-Guggulsterone (E)-Guggulsterone	Structural Classification Classification of Application Fields Commiphora myrrha (Nees) Engl. Source classification Metabolic Disease Plants Burseraceae Disease Research Fields Steroids	Drug Metabolite
(-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol	Infection Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Bacterial Antibiotic
(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol is an active constituent of the aerial parts of Angelica sinensis. (S)-1-(4-Hydroxyphenyl)ethane-1,2-diol significantly inhibits the growth of Aeromonas hydrophila. Anticoagulative and antibiotic activities .

Umbellulone	Other Monoterpenes Terpenoids Source classification Myrtaceae Plants Myrtus communis L.	TRP Channel
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism .

Narirutin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Rutaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Citrus	Bacterial
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

Stachydrine hydrochloride 3 Publications Verification	Structural Classification Alkaloids Pyrrole Alkaloids Classification of Application Fields Labiatae Source classification Lactuca perennis Plants Disease Research Fields Cancer	NF-κB Endogenous Metabolite
Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases . Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities .

Corymbiferin	Structural Classification other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Others
Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells .

Methyl linoleate	Structural Classification Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Tyrosinase
Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins .

Irisflorentin	Flavonoids Iridaceae Classification of Application Fields Source classification Plants Belamcanda chinensis (Linn.) Redouté Inflammation/Immunology Disease Research Fields Isoflavones	NO Synthase
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

Orcinol glucoside	Curculigo orchioides Gaertn. Monophenols Source classification Phenols Plants Amaryllidaceae	Wnt
Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

2-Hydroxyemodin	Quinones other families Classification of Application Fields Anthraquinones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Drug Metabolite
2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system .

Withanone	Structural Classification Source classification Withania somnifera Plants Solanaceae Steroids	iGluR
Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells .

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active constituent

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Natural
Products